Piperidin-4-ol → HCID 67214953, compound

HRID 1983199Notes

Reaction equation

HRID 1983199 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:13]3[C:14]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[N:15][O:16][C:17]=3[CH3:18])=[N:11][N:12]=2)=[CH:4][N:3]=1.[OH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH3:18][C:17]1[O:16][N:15]=[C:14]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]=1[C:10]1[O:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:29]3[CH2:30][CH2:31][CH:26]([OH:25])[CH2:27][CH2:28]3)=[N:3][CH:4]=2)=[N:12][N:11]=1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 86613584HCID 86613584, compound

Product 1

HCID 67214953HCID 67214953, compoundYield 7%

Procedure

As described for example 136b, 2-chloro-5-[5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-pyridine (200 mg, 0.59 mmol) was converted using 4-hydroxypiperidine instead of morpholine to the title compound (17 mg, 7%) which was obtained as a light yellow solid. MS: m/e=404.5 [M+H]+.

Sources & evidence

ORD record
ord-db4b7e427a804d2c9cf436f0a00bd164
Source dataset
uspto-grants-2009_06
Patent number
US07541372B2

Reaction notes

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