反应详情

温度

110 °C

To 288 mg of 3-benzo[b]thiophen-2-yl-1H-5-indazolecarbonitrile were added 3 ml of glacial acetic acid, 1 ml of water and 0.8 ml of concentrated sulfuric acid, and the mixture was stirred at 110° C. for 4 hours. After standing to cool, the mixture was added with 120 ml of ethyl acetate, sequentially washed with water and brine, dried over anhydrous magnesium sulfate. After filtering the organic layer through a silica gel pat, the solvent was evaporated, to give 307 mg of the title compound as ocher yellow crystals.

1. temperatureto cool
2. washsequentially washed with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationAfter filtering the organic layer through a silica gel pat
5. customthe solvent was evaporated