反应详情

温度

120 °C

A mixture of 6-methoxy-2-methylquinoline (999 mg, 5.77 mmol), NBS (1.03 g, 5.77 mmol), AIBN (153 mg) and chlorobenzene (10 mL) was stirred at 120° C. for 2 hours, then added with AIBN (153 mg) again and further stirred for 4 hours with heating. The solvent was evaporated under reduced pressure, and then the residue was extracted with ether. The solvent was evaporated, and the residue was recrystallized from ethanol to obtain 6-methoxy-2-bromomethylquinoline as white powder (yield: 400 mg, 1.59 mmol, 28%).

1. stirringfurther stirred for 4 hours
2. temperaturewith heating
3. customThe solvent was evaporated under reduced pressure
4. extractionthe residue was extracted with ether
5. customThe solvent was evaporated
6. customthe residue was recrystallized from ethanol