反应详情

A mixture of 6-methoxy-2-bromomethylquinoline (0.076 g, 0.302 mmol), ethylenediamine (5 μL, 0.0755 mmol), potassium carbonate (0.125 g, 0.904 mmol) and acetonitrile (6 mL) was refluxed by heating for 14 hours. The solvent was evaporated under reduced pressure, and then the residue was separated by phase separation using chloroform and water. The organic layer was dried, and then the solvent was evaporated. The residue was washed with ethanol to obtain the objective compound as white powder (yield: 18.7 mg, 33%).

1. temperaturewas refluxed
2. temperatureby heating for 14 hours
3. customThe solvent was evaporated under reduced pressure
4. customthe residue was separated by phase separation
5. customThe organic layer was dried
6. customthe solvent was evaporated
7. washThe residue was washed with ethanol