Phenol → HCID 68844355, compound

HRID 1983573Notes

Reaction equation

HRID 1983573 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:12]#[N:13]>CCOCC>[CH3:18][O:17][C:16]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][C:9]=1[O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 996PhenolHCID 7360493-Bromo-4-methoxybenzonitrile

Product 1

HCID 68844355HCID 68844355, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Phenol and 3-bromo-4-methoxybenzonitrile were subjected to Ullman ether coupling according to the procedure described in synthetic method 9 to afford product as a white solid: 1H NMR (CDCl3) δ 7.43 (dd, J=8.6, 2.0 Hz, 1H), 7.40-7.32 (m, 2H), 7.19-7.11 (m, 2H), 7.03 (d, J=8.6 Hz, 1H), 7.01-6.94 (m, 2H), 3.93 (s, 3H) ppm.

Workup

  1. customto afford product as a white solid

Sources & evidence

ORD record
ord-bb3893fbe558426686537b18957754b9
Source dataset
uspto-grants-2009_06
Patent number
US07541466B2

Reaction notes

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