Benzonitrile, 4-bromo- → HCID 178461988, compound

HRID 1983594Notes

Reaction equation

HRID 1983594 reaction equation
[CH3:1][CH:2]1[S:6][C:5]([NH:7][C@H:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])[CH3:9])=[N:4][C:3]1=[O:17].Br[C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=1.CC1(C2C=CC(C#N)=CC=2)SC(N[C@H](C2C=CC=CC=2C(F)(F)F)C)=NC1=O>>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C@@H:8]([NH:7][C:5]1[S:6][C:2]([C:19]2[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=2)([CH3:1])[C:3](=[O:17])[N:4]=1)[CH3:9]

Participants

4

Reactant 3

HCID 12162Benzonitrile, 4-bromo-HCID 178435110HCID 178435110, compoundHCID 178461986HCID 178461986, compound

Product 1

HCID 178461988HCID 178461988, compound

Procedure

The title compound was prepared from the reaction of 5-methyl-2-((S)-1-(2-fluorophenyl)ethylamino)thiazol-4(5H)-one with 4-bromobenzonitrile using the procedure described for 2a. MS (ESI, pos. ion) m/z: 354 (M+1).

Sources & evidence

ORD record
ord-c7e2571844bd44fd93447d38268f2bea
Source dataset
uspto-grants-2009_06
Patent number
US07541474B2

Reaction notes

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