Benzonitrile, 4-bromo- → HCID 178461989, compound

HRID 1983596Notes

Reaction equation

HRID 1983596 reaction equation
[CH3:1][CH:2]1[S:6][C:5]([NH:7][C@H:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH3:9])=[N:4][C:3]1=[O:17].Br[C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=1.CC1(C2C=CC(C#N)=CC=2)SC(N[C@H](C2C=CC=CC=2C(F)(F)F)C)=NC1=O>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:8]([NH:7][C:5]2[S:6][C:2]([C:19]3[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=3)([CH3:1])[C:3](=[O:17])[N:4]=2)[CH3:9])=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 12162Benzonitrile, 4-bromo-HCID 178435111HCID 178435111, compoundHCID 178461986HCID 178461986, compound

Product 1

HCID 178461989HCID 178461989, compound

Procedure

The title compound was prepared from the reaction of 5-methyl-2-((S)-1-(4-fluorophenyl)ethylamino)thiazol-4(5H)-one with 4-bromobenzonitrile using the procedure described for 2a. MS (ESI, pos. ion) m/z: 354 (M+1).

Sources & evidence

ORD record
ord-95f15d759b474b25b33fa6149049932d
Source dataset
uspto-grants-2009_06
Patent number
US07541474B2

Reaction notes

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