Bromobenzene → 2-(2-bicyclo[2.2.1]heptanylamino)-5-methyl-5-phenyl-1,3-thiazol-4-one

HRID 1983599Notes

Reaction equation

HRID 1983599 reaction equation
C12CC(CC1)CC2NC1SC(C)C(=O)N=1.BrC1C=CC=CC=1.[CH3:23][C:24]1([C:43]2[CH:50]=[CH:49][C:46](C#N)=[CH:45][CH:44]=2)[S:28][C:27]([NH:29][C@H:30]([C:32]2C=[CH:36][CH:35]=[CH:34][C:33]=2[C:38](F)(F)F)C)=[N:26][C:25]1=[O:42]>>[CH:35]12[CH2:34][CH:33]([CH2:38][CH2:36]1)[CH2:32][CH:30]2[NH:29][C:27]1[S:28][C:24]([CH3:23])([C:43]2[CH:44]=[CH:45][CH:46]=[CH:49][CH:50]=2)[C:25](=[O:42])[N:26]=1

Participants

4

Reactant 3

HCID 7961BromobenzeneHCID 178435098HCID 178435098, compoundHCID 178461986HCID 178461986, compound

Product 1

HCID 1784216002-(2-bicyclo[2.2.1]heptanylamino)-5-methyl-5-phenyl-1,3-thiazol-4-one

Procedure

The title compound was prepared from the reaction of 2-(bicyclo[2.2. 1]heptan-2-ylamino)-5-methylthiazol-4(5H)-one with bromobezene using the procedure described for 2a. MS (ESI, pos. ion) m/z: 301(M+1). % de (chiral LC): 10%.

Sources & evidence

ORD record
ord-97361658582a44c2bfe42ebe75166f2b
Source dataset
uspto-grants-2009_06
Patent number
US07541474B2

Reaction notes

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