HCID 57713314, compound → HCID 68867444, compound

HRID 1983861Notes

Reaction equation

HRID 1983861 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([N+:12]([O-])=O)=[CH:4][C:3]=1[OH:15].[H][H]>C1COCC1.[Ni]>[NH2:12][C:5]1[C:6]([C:8]([F:11])([F:9])[F:10])=[CH:7][C:2]([F:1])=[C:3]([OH:15])[CH:4]=1

Participants

5

Reactant 2

HCID 57713314HCID 57713314, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68867444HCID 68867444, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Raney-Ni (0.5 g) was added to a solution of 2-fluoro-5-nitro-4-(trifluoromethyl)phenol obtained in Reference Example 17 (0.5 g) in THF (5 ml), and the mixture was stirred for 2 hours in a hydrogen atmosphere. The catalyst was removed by filtration and the catalyst was washed with THF. The combined filtrate and washings were diluted with THF to obtain a solution of 5-amino-2-fluoro-4-(trifluoromethyl)phenol in THF (50 ml).

Workup

  1. customThe catalyst was removed by filtration
  2. washthe catalyst was washed with THF
  3. additionThe combined filtrate and washings were diluted with THF

Sources & evidence

ORD record
ord-0ce59d1b3d9b4b549d9c144b1a7f0b2a
Source dataset
uspto-grants-2009_06
Patent number
US07541478B2

Reaction notes

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