Naphthalic anhydride, 3-nitro- → 2-{2-[(2-hydroxyethyl)amino]4-methoxyphenyl}-5-nitro-1H-benzo-[de]isoquinolin-1,3(2H)-dione

HRID 1983967노트

반응식

HRID 1983967 반응식
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[NH2:13].[N+:14]([C:17]1[CH:18]=[C:19]2[C:30](=O)[O:29][C:27](=[O:28])[C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([CH:26]=1)[C:20]2=3)([O-:16])=[O:15]>C(N(CCO)C1C=CC(N2C(=O)C3C=CC([N+]([O-])=O)=C4C=3C(=CC=C4)C2=O)=CC=1)C>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[N:13]1[C:30](=[O:29])[C:19]2[CH:18]=[C:17]([N+:14]([O-:16])=[O:15])[CH:26]=[C:25]3[C:20]=2[C:21](=[CH:22][CH:23]=[CH:24]3)[C:27]1=[O:28]

참가 물질

4

반응물 2

HCID 18194Naphthalic anhydride, 3-nitro-HCID 68830082N-(2-hydroxyethyl)-5-methoxy-2-aminoaniline

생성물 1

HCID 688283552-{2-[(2-hydroxyethyl)amino]4-methoxyphenyl}-5-nitro-1H-benzo-[de]isoquinolin-1,3(2H)-dione

시약·촉매·용매 1

HCID 866134062-{4-[ethyl(2-hydroxyethyl)amino]phenyl}-6-nitro-1H-benzo[de]isoquinolin-1,3(2H)-dione용매

실험 절차

The reaction of N-(2-hydroxyethyl)-5-methoxy-2-aminoaniline with 3-nitronaphthalene-1,8-dicarboxylic anhydride in imidazole (synthesis and work-up as in Example 2, Step 1) afforded the product as a dark-red powder. For purification, the crude product in ethanol/acetone was filtered through a bed of silica gel UV/Vis (CHCl3: λmax: 411, 524 nm

출처 및 근거

ORD 기록
ord-0291e992f573475d9f57775214d5b87e
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07544215B2

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