反应详情

A mixture of 5-(piperazin-1-yl)-1H-indole (3.37 g, 0.017 mol), (S)-3-(2-bromoethyl)-2,3-dihydro-1H-indole-1-carboxylic acid amide (3.0 g, 0.11 mol), potassium carbonate (2.31 g, 0.017 mol) in butanone (450 mL) was boiled under reflux for 12 h. The mixture was filtered, concentrated in vacuo, and the residue was purified by flash chromatography (ethyl acetate/ethanol/triethylamine 70:25:5). The purified residue was precipitated from ethyl acetate to give the title compound as a white solid (3.0 g). Assignment of the optical rotation was done in dimethyl sulfoxide.

1. temperatureunder reflux for 12 h
2. filtrationThe mixture was filtered
3. concentrationconcentrated in vacuo
4. customthe residue was purified by flash chromatography (ethyl acetate/ethanol/triethylamine 70:25:5)
5. customThe purified residue was precipitated from ethyl acetate