Chloroacetamide → HCID 68854468, compound

HRID 1984009Notes

Reaction equation

HRID 1984009 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C@H:3]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:19]=[C:20]4[CH:26]=[CH:25][NH:24][C:21]4=[CH:22][N:23]=3)[CH2:14][CH2:13]2)[CH2:2]1.[Cl:27][CH2:28][C:29]([NH2:31])=[O:30]>CS(C)=O>[ClH:27].[ClH:27].[NH:24]1[C:21]2=[CH:22][N:23]=[C:18]([N:15]3[CH2:16][CH2:17][N:12]([CH2:11][CH2:10][C@H:3]4[C:4]5[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=5)[N:1]([CH2:28][C:29]([NH2:31])=[O:30])[CH2:2]4)[CH2:13][CH2:14]3)[CH:19]=[C:20]2[CH:26]=[CH:25]1

Participants

4

Reactant 2

HCID 6580ChloroacetamideHCID 68855321HCID 68855321, compound

Product 1

HCID 68854468HCID 68854468, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

from 5-{4-[(S)-2-(2,3-dihydro-1H-indol-3-yl)-ethyl]-piperazin-1-yl}-1H-pyrrolo[2,3-c]pyridine and 2-chloroacetamide. Assignment of the optical rotation was done in dimethyl sulfoxide.

Sources & evidence

ORD record
ord-7abafd4a11ef4a858943ee3c0238f8a0
Source dataset
uspto-grants-2009_06
Patent number
US07544685B2

Reaction notes

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