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HRID1984070

反应详情

EQUATION

反应方程式

HRID 1984070 的结构方程式

REACTANTS

反应物

2
结构：C#C[Si](C)(C)C
HCID66111

Trimethylsilylacetylene

C5H10Si

结构：COc1c(C)cnc(Cn2cc(I)c3c(Cl)nc(NC(=O)C(C)(C)C)nc32)c1C
HCID21883140

未命名化合物

PRODUCTS

生成物

1
结构：COc1c(C)cnc(Cn2cc(C#C[Si](C)(C)C)c3c(Cl)nc(NC(=O)C(C)(C)C)nc32)c1C
HCID57713844

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by Sonogashira coupling of N-[4-chloro-5-iodo-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethyl-propionamide (see Example 1) with ethynyl-trimethylsilane according to the General Procedure A. tR=7.48 min. 1H NMR (CDCl3) δ 8.18 (s, 2H), 7.38 (s, 1H), 5.49 (s, 2H), 3.74 (s, 3H), 2.24 (s, 6H), 1.35 (s, 9H), 0.24 (s, 9H).