HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1984086Generated: October 31, 2026
1-Methylpiperazine → 1-Methyl-4-(pent-4-ynyl)piperazine
https://huagongshe.com/reaction/1984086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Pent-4-yn-1-yl methanesulfonate | HCID 12476209 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 1-Methyl-4-(pent-4-ynyl)piperazine | HCID 23446116 | — |
Reaction Steps
A mixture of pent-4-ynyl methanesulfonate (887 mg) and N-methyl piperazine (607 μL) was heated to 80° C. for 4.5 h, diluted with 1,2-dichloroethane (5 mL) and heated to 70° C. for 18 h. Saturated aq. NaHCO3 was added (10 mL) and the mixture was extracted with DCM (3×40 mL), dried over Na2SO4, and concentrated to afford 1-methyl-4-(pent-4-ynyl)piperazine (0.23 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07544672B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-b5e10e9eb3a24f1dbeccb96d1c168c38 |
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| Source note | uspto-grants-2009_06 |
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