反应详情

温度

80 °C

A mixture of pent-4-ynyl methanesulfonate (887 mg) and N-methyl piperazine (607 μL) was heated to 80° C. for 4.5 h, diluted with 1,2-dichloroethane (5 mL) and heated to 70° C. for 18 h. Saturated aq. NaHCO3 was added (10 mL) and the mixture was extracted with DCM (3×40 mL), dried over Na2SO4, and concentrated to afford 1-methyl-4-(pent-4-ynyl)piperazine (0.23 g).

1. temperatureheated to 70° C. for 18 h
2. extractionthe mixture was extracted with DCM (3×40 mL)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated