HRID1984123

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID76497

2,2'-[(4-Methylphenyl)imino]diethanol

C11H17NO2

结构：Cc1oc(-c2ccccc2)nc1CCOc1ccc(C[C@H](N)C(=O)O)cc1Br

HCID69063835

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(N2CCN([C@@H](Cc3ccc(OCCc4nc(-c5ccccc5)oc4C)c(Br)c3)C(=O)O)CC2)cc1

HCID11556228

未命名化合物

收率 24%

PROCEDURE

实验过程

Following the procedures described in Example 1, Intermediate 3B was used in place of Intermediate 3A, and 2,2′-(p-tolylazanediyl)diethanol was used in place of 2,2′-(m-tolylazanediyl)diethanol to give (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-2-(4-p-tolyl-piperazin-1-yl)-propionic acid as a white solid with the yield of 24% and mp of 203-205° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f6801502c89e483f84c48ba3e497310e
来源数据集: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07544687B2
来源说明: uspto-grants-2009_06

反应 SMILES

[NH2:1][C@@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[O:19][C:20]=2[CH3:21])=[C:9]([Br:28])[CH:8]=1)[C:3]([OH:5])=[O:4].[C:29]1([CH3:42])[CH:34]=[CH:33][C:32]([N:35]([CH2:39][CH2:40]O)[CH2:36][CH2:37]O)=[CH:31][CH:30]=1>>[Br:28][C:9]1[CH:8]=[C:7]([CH2:6][C@H:2]([N:1]2[CH2:40][CH2:39][N:35]([C:32]3[CH:31]=[CH:30][C:29]([CH3:42])=[CH:34][CH:33]=3)[CH2:36][CH2:37]2)[C:3]([OH:5])=[O:4])[CH:12]=[CH:11][C:10]=1[O:13][CH2:14][CH2:15][C:16]1[N:17]=[C:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[O:19][C:20]=1[CH3:21]