4-(4-Nitrophenyl)piperazin-1-ylethylamine → 1-t-Butyl-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethyl-5-propylpyrazole

HRID 1984167Notes

Reaction equation

HRID 1984167 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][NH2:18])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:19]([C:22]1[N:26]([C:27]([CH3:30])([CH3:29])[CH3:28])[N:25]=[C:24]([CH:31]=O)[CH:23]=1)[CH2:20][CH3:21]>>[C:27]([N:26]1[C:22]([CH2:19][CH2:20][CH3:21])=[CH:23][C:24]([CH2:31][NH:18][CH2:17][CH2:16][N:13]2[CH2:12][CH2:11][N:10]([C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=3)[CH2:15][CH2:14]2)=[N:25]1)([CH3:30])([CH3:29])[CH3:28]

Participants

3

Reactant 2

HCID 289138874-(4-Nitrophenyl)piperazin-1-ylethylamineHCID 862610955-Propyl-1-t-butylpyrazole-3-carbaldehyde

Product 1

HCID 160387791-t-Butyl-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethyl-5-propylpyrazoleYield 95.6%

Procedure

Compound 50 was prepared using the same method as that of Example 1 except that 4-(4-nitrophenyl)piperazin-1-ylethylamine and 5-propyl-1-t-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-99bb109aa17e4f569b713399e80bd9d3
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

Loading…