1-Tert-butyl-5-iso-butyl-3-formylpyrazole → 1-t-Butyl-5-iso-butyl-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethylpyrazole

HRID 1984169Notes

Reaction equation

HRID 1984169 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][NH2:18])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:19]([N:23]1[C:27]([CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:26][C:25]([CH:32]=O)=[N:24]1)([CH3:22])([CH3:21])[CH3:20]>>[C:19]([N:23]1[C:27]([CH2:28][CH:29]([CH3:30])[CH3:31])=[CH:26][C:25]([CH2:32][NH:18][CH2:17][CH2:16][N:13]2[CH2:12][CH2:11][N:10]([C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=3)[CH2:15][CH2:14]2)=[N:24]1)([CH3:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 224935831-Tert-butyl-5-iso-butyl-3-formylpyrazoleHCID 289138874-(4-Nitrophenyl)piperazin-1-ylethylamine

Product 1

HCID 160387811-t-Butyl-5-iso-butyl-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethylpyrazoleYield 74.5%

Procedure

Compound 52 was prepared using the same method as that of Example 1 except that 4-(4-nitrophenyl)piperazin-1-ylethylamine and 1-t-butyl-5-iso-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-0a7e506f9eaa4a4488cc24c4eda5aff5
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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