4-(4-Nitrophenyl)piperazin-1-ylethylamine → 1-t-Butyl-5-(4-methylphenyl)-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethylpyrazole

HRID 1984173Notes

Reaction equation

HRID 1984173 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][NH2:18])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:19]([N:23]1[C:27]([C:28]2[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=2)=[CH:26][C:25]([CH:35]=O)=[N:24]1)([CH3:22])([CH3:21])[CH3:20]>>[C:19]([N:23]1[C:27]([C:28]2[CH:29]=[CH:30][C:31]([CH3:34])=[CH:32][CH:33]=2)=[CH:26][C:25]([CH2:35][NH:18][CH2:17][CH2:16][N:13]2[CH2:12][CH2:11][N:10]([C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=3)[CH2:15][CH2:14]2)=[N:24]1)([CH3:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 289138874-(4-Nitrophenyl)piperazin-1-ylethylamineHCID 866110591-t-Butyl-5-(4-methylphenyl)pyrazole-3-carbaldehyde

Product 1

HCID 160388531-t-Butyl-5-(4-methylphenyl)-3-{2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl}aminomethylpyrazoleYield 69.4%

Procedure

Compound 56 was prepared using the same method as that of Example 1 except that 4-(4-nitrophenyl)piperazin-1-ylethylamine and 1-t-butyl-5-(4-methylphenyl)pyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-a1997f9a20ab462b8bee9fcd23f10ddc
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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