2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 1-t-Butyl-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-5-propyl pyrazole
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[CH2:17]([C:20]1[N:24]([C:25]([CH3:28])([CH3:27])[CH3:26])[N:23]=[C:22]([CH:29]=O)[CH:21]=1)[CH2:18][CH3:19]>>[C:25]([N:24]1[C:20]([CH2:17][CH2:18][CH3:19])=[CH:21][C:22]([CH2:29][NH:16][CH2:15][CH2:14][N:11]2[CH2:10][CH2:9][N:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[CH2:13][CH2:12]2)=[N:23]1)([CH3:28])([CH3:27])[CH3:26]Participants
3
Procedure
Compound 62 was prepared using the same method as Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 5-propyl-1-t-butylpyrazole-3-carbaldehyde were used.
Sources & evidence
- ORD record
- ord-76ea09f21f1747a5a3bb15b9dbf71aa4
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07544686B2
Reaction notes
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