2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 1,5-Diphenyl-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethylpyrazole

HRID 1984182Notes

Reaction equation

HRID 1984182 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[C:17]1([N:23]2[C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:26][C:25]([CH:34]=O)=[N:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:17]1([N:23]2[C:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:26][C:25]([CH2:34][NH:16][CH2:15][CH2:14][N:11]3[CH2:10][CH2:9][N:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])[CH2:13][CH2:12]3)=[N:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 534070841,5-Diphenyl-1H-pyrazole-3-carbaldehyde

Product 1

HCID 160389251,5-Diphenyl-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethylpyrazoleYield 74.5%

Procedure

Compound 68 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 1,5-diphenylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-309a9cba3d9a40cb8d624c2d5d36c4ff
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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