2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 1-t-Butyl-5-(4-chlorophenyl)-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethylpyrazole

HRID 1984184Notes

Reaction equation

HRID 1984184 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[N:28]([C:29]([CH3:32])([CH3:31])[CH3:30])[N:27]=[C:26]([CH:33]=O)[CH:25]=2)=[CH:20][CH:19]=1>>[C:29]([N:28]1[C:24]([C:21]2[CH:20]=[CH:19][C:18]([Cl:17])=[CH:23][CH:22]=2)=[CH:25][C:26]([CH2:33][NH:16][CH2:15][CH2:14][N:11]2[CH2:10][CH2:9][N:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[CH2:13][CH2:12]2)=[N:27]1)([CH3:32])([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 866110605-(4-Chlorophenyl)-1-t-butylpyrazole-3-carbaldehyde

Product 1

HCID 160388571-t-Butyl-5-(4-chlorophenyl)-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethylpyrazoleYield 74.2%

Procedure

Compound 70 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 5-(4-chlorophenyl)-1-t-butylpyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-1bfaf20eb2944b23b8080ded050ce99c
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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