2-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamine → 5-(4-Cyclohexylphenyl)-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazole

HRID 1984185Notes

Reaction equation

HRID 1984185 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1.[CH:17]1([C:23]2[CH:28]=[CH:27][C:26]([C:29]3[N:33]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[N:32]=[C:31]([CH:40]=O)[CH:30]=3)=[CH:25][CH:24]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH:17]1([C:23]2[CH:28]=[CH:27][C:26]([C:29]3[N:33]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[N:32]=[C:31]([CH2:40][NH:16][CH2:15][CH2:14][N:11]4[CH2:10][CH2:9][N:8]([C:3]5[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=5[F:1])[CH2:13][CH2:12]4)[CH:30]=3)=[CH:25][CH:24]=2)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 110095812-[4-(2-Fluorophenyl)piperazin-1-yl]ethanamineHCID 862611315-(4-Cyclohexylphenyl)-1-phenylpyrazole-3-carbaldehyde

Product 1

HCID 160389975-(4-Cyclohexylphenyl)-3-{2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl}aminomethyl-1-phenylpyrazoleYield 64.8%

Procedure

Compound 71 was prepared using the same method as that of Example 1 except that 4-(2-fluorophenyl)piperazin-1-ylethylamine and 5-(4-cyclohexylphenyl)-1-phenyl pyrazole-3-carbaldehyde were used.

Sources & evidence

ORD record
ord-0ba99d87fd6b4512b76c72721ba2bb62
Source dataset
uspto-grants-2009_06
Patent number
US07544686B2

Reaction notes

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