4-(4-Chlorobenzhydryl)piperazin-1-ylethylamine → 1-t-Butyl-3-{2-[4-(4-chlorobenzhydryl)piperazin-1-yl]ethyl}aminomethyl-5-(4-chlorophenyl)pyrazole
Reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH:6]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][NH2:21])[CH2:15][CH2:14]2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Cl:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[N:35]([C:36]([CH3:39])([CH3:38])[CH3:37])[N:34]=[C:33]([CH:40]=O)[CH:32]=2)=[CH:27][CH:26]=1>>[C:36]([N:35]1[C:31]([C:28]2[CH:27]=[CH:26][C:25]([Cl:24])=[CH:30][CH:29]=2)=[CH:32][C:33]([CH2:40][NH:21][CH2:20][CH2:19][N:16]2[CH2:15][CH2:14][N:13]([CH:6]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:23][CH:22]=3)[CH2:18][CH2:17]2)=[N:34]1)([CH3:39])([CH3:38])[CH3:37]Participants
3
Procedure
Compound 100 was prepared using the same method as that of Example 1 except that 4-(4-chlorobenzhydryl)piperazin-1-ylethylamine and 5-(4-chlorophenyl)-1-t-butyl pyrazole-3-carbaldehyde were used.
Sources & evidence
- ORD record
- ord-433c65cf742a4c4c925d51b5553585d5
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07544686B2
Reaction notes
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