Water → HCID 10001356, compound

HRID 1984256Notes

Reaction equation

HRID 1984256 reaction equation
[C:1]([C:3]1[N:8]=[C:7]([N:9]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24]OS(C)(=O)=O)=[CH:18][CH:17]=2)[CH2:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH:6]=[CH:5][N:4]=1)#[N:2].[C:30]([C:32]1[N:37]=[C:36]([N:38]([CH2:44][C:45]2[CH:50]=[CH:49][C:48]([CH:51]([CH3:58])[CH2:52][O:53][S:54]([CH3:57])(=[O:56])=[O:55])=[CH:47][CH:46]=2)[CH2:39][C:40]([CH3:43])([CH3:42])[CH3:41])[CH:35]=[CH:34][N:33]=1)#[N:31].O>CN(C=O)C>[CH3:12][C:11]([CH3:14])([CH3:13])[CH2:10][N:9]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][N:38]2[CH2:44][CH2:45][CH2:50][CH2:49][CH2:48]2)=[CH:18][CH:17]=1)[C:7]1[CH:6]=[CH:5][N:4]=[C:3]([C:1]#[N:2])[N:8]=1.[C:30]([C:32]1[N:37]=[C:36]([N:38]([CH2:44][C:45]2[CH:46]=[CH:47][C:48]([CH:51]([CH3:58])[CH2:52][O:53][S:54]([CH3:57])(=[O:55])=[O:56])=[CH:49][CH:50]=2)[CH2:39][C:40]([CH3:43])([CH3:42])[CH3:41])[CH:35]=[CH:34][N:33]=1)#[N:31]

Participants

6

Reactant 3

HCID 962WaterHCID 57714114HCID 57714114, compoundHCID 57714121HCID 57714121, compound

Product 2

HCID 10001356HCID 10001356, compoundHCID 57714114HCID 57714114, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of methanesulfonic acid 3-(4-{[(2-cyano-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-amino]-methyl}-phenyl)-propyl ester and methanesulfonic acid 2-(4-{[(2-cyano-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-amino]-methyl}-phenyl)-propyl ester (in ratio of 3:1) (130 mg, 0.31 mmoles) is dissolved in 3 ml of DMF and 1-piperizine (0.06 ml, 0.64 mmoles) is added at rt. The mixture is stirred at rt for overnight. Water is added and the organic layer is extracted with AcOEt, dried over magnesum sulfate and concentrated. The crude product is purified by silica gel column chromatography to give 56 mg of desired 4-{(2,2-dimethyl-propyl)-[4-(3-piperidin-1-yl-propyl)-benzyl]-amino}-pyrimidine-2-carbonitrile (A) in 56% yield and 24 mg of desired methanesulfonic acid 2-(4-{[(2-cyano-pyrimidin-4-yl)-(2,2-dimethyl-propyl)-amino]-methyl}-phenyl)-propyl ester (B) in 18% yield.

Workup

  1. extractionthe organic layer is extracted with AcOEt
  2. dry with materialdried over magnesum sulfate
  3. concentrationconcentrated
  4. customThe crude product is purified by silica gel column chromatography

Sources & evidence

ORD record
ord-aa5c87cb760c4f89a7fc751be0f468c7
Source dataset
uspto-grants-2009_06
Patent number
US07544688B2

Reaction notes

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