Benzyl Bromide → [1-Benzyl-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

HRID 19843Notes

Reaction equation

HRID 19843 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15]([C:20]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:21])=[CH:14]3)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH2:28](Br)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([N:16]1[C:17]2[C:13](=[CH:12][C:11]([O:10][CH:7]3[CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:9][CH2:8]3)=[CH:19][CH:18]=2)[CH:14]=[C:15]1[C:20]([N:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1)=[O:21])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 11717680(5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone2×

Product 1

HCID 16739388[1-Benzyl-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

Procedure

In analogy to the procedure described for the synthesis of example 1, the title compound was synthesized from [5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone (intermediate 2) and benzyl bromide. The title compound was obtained in 4% yield as white solid. MS (m/e): 462.2 (MH+, 100%).

Workup

  1. customIn analogy to the procedure described for the synthesis of example 1

Sources & evidence

ORD record
ord-c022ecaf67d6430282e88dea5a80a881
Source dataset
uspto-grants-2010_06
Patent number
US07745479B2

Reaction notes

Loading…