Ammonium Hydroxide → HCID 66958295, compound

HRID 1984368Notes

Reaction equation

HRID 1984368 reaction equation
[CH2:1]([N:8]1[C:12]([CH3:13])=[CH:11][C:10]([C:14]([O:16]CC)=O)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[NH4+:20]>CO>[CH2:1]([N:8]1[C:12]([CH3:13])=[CH:11][C:10]([C:14]([NH2:20])=[O:16])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 2755348ethyl 1-benzyl-5-methyl-1H-pyrazole-3-carboxylate

Product 1

HCID 66958295HCID 66958295, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
125 °C

Procedure

A mixture of ethyl 1-benzyl-5-methyl-1H-pyrazole-3-carboxylate (57.57 g, 0.236 mol), concentrated ammonium hydroxide (114 mL), and methanol (114 mL) was heated at 125° C. for 39 hours in a pressure vessel. After cooling to ambient temperature, the vessel was placed in an ice bath and the reaction solution was stirred for 30 minutes until a precipitate formed. The precipitate was isolated by filtration and washed with water to yield 28.22 g of 1-benzyl-5-methyl-1H-pyrazole-3-carboxamide.

Workup

  1. temperatureAfter cooling to ambient temperature
  2. customthe vessel was placed in an ice bath
  3. customformed
  4. customThe precipitate was isolated by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-99faaf667b254a33ba88ceae1cf95593
Source dataset
uspto-grants-2009_06
Patent number
US07544697B2

Reaction notes

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