HCID 57717605, compound → HCID 66959065, compound

HRID 1984441Notes

Reaction equation

HRID 1984441 reaction equation
C([N:8]1[C:20]([CH3:21])=[C:19]2[C:10]([C:11]([NH2:22])=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=32)=[N:9]1)C1C=CC=CC=1>Br.C(O)(=O)C>[CH3:21][C:20]1[NH:8][N:9]=[C:10]2[C:19]=1[C:18]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:12]=[C:11]2[NH2:22]

Participants

5

Reactant 2

HCID 57717605HCID 57717605, compoundHCID 178506046HCID 178506046, compound

Product 1

HCID 66959065HCID 66959065, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Conditions

Temperature
140 °C

Procedure

A poly(tetrafluoroethylene)-lined steel pressure vessel containing a solution of 2-benzyl-1-methyl-2H-pyrazolo[3,4-c]quinolin-4-amine (prepared as described in Example 36, 0.8821 g, 3.06 mmol) in anhydrous hydrogen bromide in acetic acid (10 mL) was heated in a 140° C. oven for 17 hours. The vessel was allowed to cool to room temperature. A solid formed that was isolated by filtration and washed with water to yield 1-methyl-2H-pyrazolo[3,4-c]quinolin-4-amine that was used in the next step.

Workup

  1. temperatureto cool to room temperature
  2. customA solid formed that
  3. customwas isolated by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-b67b92b61dfe4c1785c1208540bec0a0
Source dataset
uspto-grants-2009_06
Patent number
US07544697B2

Reaction notes

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