2-iodo-1H-imidazole → HCID 24784183, compound

HRID 1984664Notes

Reaction equation

HRID 1984664 reaction equation
[C:1]([C:3]1[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:5][O:6][C:7]=1[CH3:8])#[CH:2].I[C:16]1[NH:17][CH:18]=[CH:19][N:20]=1>>[NH:17]1[CH:18]=[CH:19][N:20]=[C:16]1[C:2]#[C:1][C:3]1[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:5][O:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 27734682-iodo-1H-imidazoleHCID 534346474-Ethynyl-5-methyl-3-phenyl-isoxazole

Product 1

HCID 24784183HCID 24784183, compoundYield 77%

Procedure

As described for example 11c, 4-ethynyl-5-methyl-3-phenyl-isoxazole (79 mg, 0.43 mmol) was converted (using 2-iodo-1H-imidazole instead of 2-chloro-4-iodopyridine) to the title compound (SiO2, heptane:ethyl acetate=95:5 to 0:100, 83 mg, 77%) which was obtained as an off-white solid. MS: m/e=250.2 [M+H]+.

Sources & evidence

ORD record
ord-ad1c4ac150f444a9bf7e449cf65e2133
Source dataset
uspto-grants-2009_06
Patent number
US07544704B2

Reaction notes

Loading…