Hydrogen Bromide → 4-(Bromomethyl)Pyridin-2-Amine Hydrobromide

Temperature

120 °C

(2-Aminopyridin-4-yl)methanol (15 g, 12 mmol) was suspended in a 47% aqueous hydrobromic acid solution (120 mL, 72 mmol) at room temperature, and the mixture was stirred for 6 hours at outer temperature 120° C. The mixture was stirred for 15 hours at room temperature, then the precipitated solid was filtered off and washed with ethyl acetate. The solid was dried under reduced pressure to give 23 g of the title reference compound as a gray solid. (Yield 71%)

1. stirringThe mixture was stirred for 15 hours at room temperature
2. filtrationthe precipitated solid was filtered off
3. washwashed with ethyl acetate
4. customThe solid was dried under reduced pressure
5. customto give 23 g of the title reference compound as a gray solid

ORD record

ord-610564d5f34b42b19a0d1d976e3d35ef

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07544703B2