反应详情

A solution of 4 N hydrochloric acid in 1,4-dioxane (5.0 mL) was added to a solution of 2-(2-tert-butoxycarbonylaminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide (Compound No. 2-1, 420 mg, 0.90 mmol) in 1,4-dioxane (5.0 mL) at room temperature, and the mixture was stirred for 12 hours. Ethanol (6.0 mL) was added to the reaction mixture, and the precipitated solid was filtered off. The solid was dried under reduced pressure at 60° C. to give 320 mg of the target compound as a colorless crystal. (Yield 88%)

1. filtrationthe precipitated solid was filtered off
2. customThe solid was dried under reduced pressure at 60° C.