Trifluoroacetic acid methylene chloride → Trifluoroacetic acid

HRID 1984790Notes

Reaction equation

HRID 1984790 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:21][CH2:20][C:19]3([CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[CH2:18][CH2:17]2)=[N:12][CH:11]=1.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29].C(Cl)Cl>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:21][CH2:20][C:19]3([CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[CH2:18][CH2:17]2)=[N:12][CH:11]=1.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]

Participants

4

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 57717460HCID 57717460, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 57717460HCID 57717460, compound

Procedure

A solution of N-(2-aminophenyl)-6-(3,9-diazaspiro[5.5]undec-3-yl)nicotinamide (10 mg, 0.022 mmol) in 2 mL of 1:1 TFA/CH2Cl2 was stirred for 1 h and concentrated, giving the title compound as a TFA salt; MS (ESI+): cal'd [M+1]+ 365.2, obs'd 365.2.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-14e713e4d78947c3b493f3469258de23
Source dataset
uspto-grants-2009_06
Patent number
US07544695B2

Reaction notes

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