Lithium Hydroxide → HCID 21921606, compound

HRID 1984812Notes

Reaction equation

C[O:2][C:3](=[O:49])[CH:4]([NH:25][C:26](=[O:48])[C:27]1[CH:32]=[C:31]([Br:33])[CH:30]=[CH:29][C:28]=1[NH:34][S:35]([C:38]1[CH:43]=[CH:42][C:41]([C:44]([CH3:47])([CH3:46])[CH3:45])=[CH:40][CH:39]=1)(=[O:37])=[O:36])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:8][CH:7]=1.[Li+].[OH-]>>[Br:33][C:31]1[CH:30]=[CH:29][C:28]([NH:34][S:35]([C:38]2[CH:39]=[CH:40][C:41]([C:44]([CH3:47])([CH3:46])[CH3:45])=[CH:42][CH:43]=2)(=[O:37])=[O:36])=[C:27]([CH:32]=1)[C:26]([NH:25][CH:4]([CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][CH:11]=1)[C:3]([OH:49])=[O:2])=[O:48]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68867816HCID 68867816, compound

Product 1

HCID 21921606HCID 21921606, compoundYield 86.5%

Procedure

2-[5-Bromo-2-(4-t-butyl-benzenesulfonylamino)-benzoylamino]-3-(2′-phenoxy-biphenyl-4-yl) propionic acid methyl ester (0.04 g, 0.054 mmol ) was treated with LiOH (2 eq, 1 N aqueous solution) according to the general procedure C to give 0.034 g of 2-[5-bromo-2-(4-t-butyl-benzenesulfonylamino)-benzoylamino]-3-(2′-phenoxy-biphenyl-4-yl) propionic acid.

Sources & evidence

ORD record: ord-62272f52ea614c249f6c9e4ef990fedd
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544699B2

Reaction notes

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