HRID1984826

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@H](Cc1ccc(-c2ccc(F)c(Cl)c2)cc1)NC(=O)c1cc2cc(Oc3ccc(C(F)(F)F)cc3)ccc2cn1

HCID57717943

未命名化合物

PRODUCTS

生成物

结构：O=C(N[C@@H](Cc1ccc(-c2ccc(F)c(Cl)c2)cc1)C(=O)O)c1cc2cc(Oc3ccc(C(F)(F)F)cc3)ccc2cn1

HCID57717857

未命名化合物

收率 76.7%

PROCEDURE

实验过程

A solution of 3-(3′-chloro-4′-fluoro-biphenyl-4-yl)-(2S)-{[6-(4-trifluoromethyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-propionic acid methyl ester (20 mg, 0.0321 mmol) was treated with LiOH (5 mg, 0.128 mmol) by the General Procedure to give 15 mg of 3-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-(2S)-{[6-(4-trifluoromethyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-propionic acid as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de13223c0adf491c8222e424cc4bc1d4
来源数据集: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07544699B2
来源说明: uspto-grants-2009_06

反应 SMILES

C[O:2][C:3](=[O:44])[C@@H:4]([NH:20][C:21]([C:23]1[N:24]=[CH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][C:29]([O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]([F:43])([F:42])[F:41])=[CH:36][CH:35]=1)=[CH:28][CH:27]=2)=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([Cl:19])[CH:13]=2)=[CH:8][CH:7]=1.[Li+].[OH-]>>[Cl:19][C:14]1[CH:13]=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([CH2:5][C@H:4]([NH:20][C:21]([C:23]3[N:24]=[CH:25][C:26]4[C:31]([CH:32]=3)=[CH:30][C:29]([O:33][C:34]3[CH:39]=[CH:38][C:37]([C:40]([F:42])([F:43])[F:41])=[CH:36][CH:35]=3)=[CH:28][CH:27]=4)=[O:22])[C:3]([OH:44])=[O:2])=[CH:7][CH:8]=2)[CH:17]=[CH:16][C:15]=1[F:18]