Lithium Hydroxide → 3-(3'-Chloro-4'-fluoro-biphenyl-4-yl)-(2S)-{[6-(4-trifluoromethyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-propionic acid
Reaction equation
C[O:2][C:3](=[O:44])[C@@H:4]([NH:20][C:21]([C:23]1[N:24]=[CH:25][C:26]2[C:31]([CH:32]=1)=[CH:30][C:29]([O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]([F:43])([F:42])[F:41])=[CH:36][CH:35]=1)=[CH:28][CH:27]=2)=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([Cl:19])[CH:13]=2)=[CH:8][CH:7]=1.[Li+].[OH-]>>[Cl:19][C:14]1[CH:13]=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([CH2:5][C@H:4]([NH:20][C:21]([C:23]3[N:24]=[CH:25][C:26]4[C:31]([CH:32]=3)=[CH:30][C:29]([O:33][C:34]3[CH:39]=[CH:38][C:37]([C:40]([F:42])([F:43])[F:41])=[CH:36][CH:35]=3)=[CH:28][CH:27]=4)=[O:22])[C:3]([OH:44])=[O:2])=[CH:7][CH:8]=2)[CH:17]=[CH:16][C:15]=1[F:18]Participants
3
Procedure
A solution of 3-(3′-chloro-4′-fluoro-biphenyl-4-yl)-(2S)-{[6-(4-trifluoromethyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-propionic acid methyl ester (20 mg, 0.0321 mmol) was treated with LiOH (5 mg, 0.128 mmol) by the General Procedure to give 15 mg of 3-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-(2S)-{[6-(4-trifluoromethyl-phenoxy)-isoquinoline-3-carbonyl]-amino}-propionic acid as a white solid.
Sources & evidence
- ORD record
- ord-de13223c0adf491c8222e424cc4bc1d4
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07544699B2
Reaction notes
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