Dichloromethane → HCID 11721387, compound

HRID 1984835Notes

Reaction equation

HRID 1984835 reaction equation
C[O:2][C:3](=[O:45])[C@@H:4]([NH:18][C:19]([C:21]1[C:30]([S:31][CH2:32][CH3:33])=[N:29][C:28]2[C:23](=[CH:24][CH:25]=[C:26]([O:34][C:35]3[CH:40]=[CH:39][C:38]([C:41]([CH3:44])([CH3:43])[CH3:42])=[CH:37][CH:36]=3)[CH:27]=2)[N:22]=1)=[O:20])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:8][CH:7]=1.C(Cl)Cl>C(Cl)Cl.CO>[C:9]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]=[CH:7][C:6]([CH2:5][C@H:4]([NH:18][C:19]([C:21]2[C:30]([S:31][CH2:32][CH3:33])=[N:29][C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:34][C:35]4[CH:36]=[CH:37][C:38]([C:41]([CH3:42])([CH3:43])[CH3:44])=[CH:39][CH:40]=4)[CH:27]=3)[N:22]=2)=[O:20])[C:3]([OH:45])=[O:2])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 57717651HCID 57717651, compound

Product 1

HCID 11721387HCID 11721387, compoundYield 75.7%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

3-Biphenyl-4-yl-(2S)-{[6-(4-tert-butyl-phenoxy)-3-ethylsulfanyl-quinoxaline-2-carbonyl]-amino}-propionic acid methyl ester (30 mg, 0.048 mmol) was hydrolyzed as described in general procedure C. Column chromatography over silica using DCM and 95:5 DCM-methanol as eluants gave the title compound (22 mg).

Sources & evidence

ORD record
ord-a1caa4c330a04a0098a35076f3290ad9
Source dataset
uspto-grants-2009_06
Patent number
US07544699B2

Reaction notes

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