HRID1984840

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COC(=O)[C@@H](N)Cc1ccc(-c2ccccc2)cc1

HCID15714801

未命名化合物

反应SMILES：CC(C)(C)c1ccc(Oc2ccc3cc(C(=O)O)nc(CC4CCCC4)c3c2)cc1

HCID18457633

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)(C)c1ccc(Oc2ccc3cc(C(=O)N[C@@H](Cc4ccc(-c5ccccc5)cc4)C(=O)O)nc(CC4CCCC4)c3c2)cc1

HCID57717698

未命名化合物

收率 93.1%

PROCEDURE

实验过程

50 mg (0.12 mmol) of 7-(4-tert-butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carboxylic acid was reacted with (2S)-amino-3-biphenyl-4-yl-propionic acid methyl ester (34.8 mg, 0.13 mmol) as described in general procedure A. The resulting ester was hydrolyzed as described in general procedure C to afford 70 mg of the title compound as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-2e9cd920e5144fc2ba4d436e24dc8717
来源数据集: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07544699B2
来源说明: uspto-grants-2009_06

反应SMILES

[C:1]([C:5]1[CH:30]=[CH:29][C:8]([O:9][C:10]2[CH:19]=[C:18]3[C:13]([CH:14]=[C:15]([C:26](O)=[O:27])[N:16]=[C:17]3[CH2:20][CH:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C[O:32][C:33](=[O:49])[C@@H:34]([NH2:48])[CH2:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)=[CH:38][CH:37]=1>>[C:39]1([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[CH:40]=[CH:41][C:36]([CH2:35][C@H:34]([NH:48][C:26]([C:15]2[N:16]=[C:17]([CH2:20][CH:21]3[CH2:22][CH2:23][CH2:24][CH2:25]3)[C:18]3[C:13]([CH:14]=2)=[CH:12][CH:11]=[C:10]([O:9][C:8]2[CH:29]=[CH:30][C:5]([C:1]([CH3:3])([CH3:4])[CH3:2])=[CH:6][CH:7]=2)[CH:19]=3)=[O:27])[C:33]([OH:32])=[O:49])=[CH:37][CH:38]=1