HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 11706247, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 68867983 | HCID 68867983 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | HCID 11706247 | HCID 11706247 | 89.3% |
Reaction Steps
A solution of (2S)-{[5-(4-tert-Butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]-amino}-3,3-dimethyl-butyric acid methyl ester (28 mg, 0.052 mmol) in THF-MeOH (2.0 mL) was treated with LiOH solution (2.0M, 0.400 mL) by the general procedure I to give 24 mg of (2S)-{[5-(4-tert-Butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]-amino}-3,3-dimethyl-butyric acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544699B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-8e5af8fe1da043038dfffdc225b78f0f |
| Source note | uspto-grants-2009_06 |