Lithium Hydroxide → HCID 11706247, compound

HRID 1984851Notes

Reaction equation

HRID 1984851 reaction equation
C[O:2][C:3](=[O:39])[C@@H:4]([NH:9][C:10]([C:12]1[N:13]=[C:14]([CH2:33][CH:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)[C:15]2[C:20]([CH:21]=1)=[C:19]([O:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:25][CH:24]=1)[CH:18]=[CH:17][CH:16]=2)=[O:11])[C:5]([CH3:8])([CH3:7])[CH3:6].[Li+].[OH-]>C1COCC1.CO>[C:29]([C:26]1[CH:27]=[CH:28][C:23]([O:22][C:19]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:20]=2[CH:21]=[C:12]([C:10]([NH:9][C@@H:4]([C:5]([CH3:8])([CH3:7])[CH3:6])[C:3]([OH:39])=[O:2])=[O:11])[N:13]=[C:14]3[CH2:33][CH:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)=[CH:24][CH:25]=1)([CH3:32])([CH3:30])[CH3:31]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 68867983HCID 68867983, compound

Product 1

HCID 11706247HCID 11706247, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

A solution of (2S)-{[5-(4-tert-Butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]-amino}-3,3-dimethyl-butyric acid methyl ester (28 mg, 0.052 mmol) in THF-MeOH (2.0 mL) was treated with LiOH solution (2.0M, 0.400 mL) by the general procedure I to give 24 mg of (2S)-{[5-(4-tert-Butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]-amino}-3,3-dimethyl-butyric acid as a white solid.

Sources & evidence

ORD record
ord-8e5af8fe1da043038dfffdc225b78f0f
Source dataset
uspto-grants-2009_06
Patent number
US07544699B2

Reaction notes

Loading…