HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 57717917, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 68867964 | HCID 68867964 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | HCID 57717917 | HCID 57717917 | 85.3% |
Reaction Steps
A solution of (2S)-{[7-(4-tert-butyl-cyclohexylcarbamoyl)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]-amino}3,3-dimethylbutyric acid methyl ester (18 mg, 0.032 mmol) in THF:MeOH(4:1, 2.0 mL) was treated with a solution of LiOH (2.0 M, 0.240 mL) by the general procedure I to give 15 mg of 2(S)-{[7-(4-tert-butyl-cyclohexylcarbamoyl)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]amino}3,3-dimethylbutyric acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544699B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-7758f6b6914e4392b3ab0e7d895e35b3 |
| Source note | uspto-grants-2009_06 |