Lithium Hydroxide → HCID 57717917, compound

HRID 1984856Notes

Reaction equation

HRID 1984856 reaction equation
C[O:2][C:3](=[O:41])[C@@H:4]([NH:9][C:10]([C:12]1[N:13]=[C:14]([CH2:35][CH:36]2[CH2:40][CH2:39][CH2:38][CH2:37]2)[C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[C:17]([C:22](=[O:34])[NH:23][CH:24]1[CH2:29][CH2:28][CH:27]([C:30]([CH3:33])([CH3:32])[CH3:31])[CH2:26][CH2:25]1)[CH:16]=2)=[O:11])[C:5]([CH3:8])([CH3:7])[CH3:6].[Li+].[OH-]>C1COCC1.CO>[C:30]([CH:27]1[CH2:28][CH2:29][CH:24]([NH:23][C:22]([C:17]2[CH:16]=[C:15]3[C:20]([CH:21]=[C:12]([C:10]([NH:9][C@@H:4]([C:5]([CH3:8])([CH3:7])[CH3:6])[C:3]([OH:41])=[O:2])=[O:11])[N:13]=[C:14]3[CH2:35][CH:36]3[CH2:37][CH2:38][CH2:39][CH2:40]3)=[CH:19][CH:18]=2)=[O:34])[CH2:25][CH2:26]1)([CH3:33])([CH3:32])[CH3:31]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 68867964HCID 68867964, compound

Product 1

HCID 57717917HCID 57717917, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

A solution of (2S)-{[7-(4-tert-butyl-cyclohexylcarbamoyl)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]-amino}3,3-dimethylbutyric acid methyl ester (18 mg, 0.032 mmol) in THF:MeOH(4:1, 2.0 mL) was treated with a solution of LiOH (2.0 M, 0.240 mL) by the general procedure I to give 15 mg of 2(S)-{[7-(4-tert-butyl-cyclohexylcarbamoyl)-1-cyclopentylmethyl-isoquinoline-3-carbonyl]amino}3,3-dimethylbutyric acid as a white solid.

Sources & evidence

ORD record
ord-7758f6b6914e4392b3ab0e7d895e35b3
Source dataset
uspto-grants-2009_06
Patent number
US07544699B2

Reaction notes

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