HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 57717844, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | Methyl L-tert-leucinate | HCID 11309583 | — |
| Reactant | HCID 18457663 | HCID 18457663 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57717844 | HCID 57717844 | 35% |
Reaction Steps
To a solution of 6-(4-tert-butyl-phenoxy)-1-cyclopentylmethyl-isoquinoline-3-carboxylic acid (50 mg, 0.124 mmol) in dry DMF (1.25 mL) was added HBTU (1.5 eq., 0.19 mmol, 71 mg), tert-butylglycine methyl ester (1.1 eq., 0.14 mmol, 25 mg) and DIEA (3.0 eq., 0.37 mmol, 0.065 mL) according to general procedure A. Purification by chromatography on silica afforded 23 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07544699B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-560ca91275a4405294b5ac918b6a8d5b |
| Source note | uspto-grants-2009_06 |