反应详情

To a solution of N2-(1-benzyl-pyrrolidin-3-yl)-N4,N4-dimethyl-quinazoline-2,4-diamine (3.3 g, 9.5 mmol) in MeOH (33 mL) was added Pd(OH)2 (660 mg). The mixture was stirred at ambient temperature under hydrogen atmosphere for 13 hr, and stirred at 50° C. for 6 hr. The mixture was filtered, concentrated, and purified by medium-pressure liquid chromatography (NH-silica gel, 1% to 3% MeOH in CHCl3) to give N4,N4-dimethyl-N2-pyrrolidin-3-yl-quinazoline-2,4-diamine (2.3 g, 93%) as a yellow oil.

1. stirringstirred at 50° C. for 6 hr
2. filtrationThe mixture was filtered
3. concentrationconcentrated
4. custompurified by medium-pressure liquid chromatography (NH-silica gel, 1% to 3% MeOH in CHCl3)