反应详情

To a solution of trans-[4-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-carbamic acid benzyl ester (5.32 g, 0.015 mol) in EtOH (200 mL) was added 10% Pd/C (50 mg). The mixture was stirred at ambient temperature under hydrogen atmosphere for 4 hr. The resulting mixture was filtered through a pad of celite and concentrated. The residue was purified by column chromatography (silica gel, 3% 2 M NH3/MeOH in CH2Cl2) to give trans-(4-amino-cyclohexylmethyl)-carbamic acid tert-butyl ester as a colorless solid (3.197 g, 95.4%).

1. filtrationThe resulting mixture was filtered through a pad of celite
2. concentrationconcentrated
3. customThe residue was purified by column chromatography (silica gel, 3% 2 M NH3/MeOH in CH2Cl2)