Hydrochloric Acid → HCID 68846786, compound

HRID 1984948Notes

Reaction equation

HRID 1984948 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][NH:16][C:17]2[N:26]=[C:25]([N:27]([CH3:29])[CH3:28])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)=[CH:11][CH:10]=1)(C)(C)C.[ClH:31].CCOCC>CO>[ClH:31].[NH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][NH:16][C:17]2[N:26]=[C:25]([N:27]([CH3:29])[CH3:28])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68850235HCID 68850235, compound

Product 1

HCID 68846786HCID 68846786, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a cooled solution of {4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-benzyl}-carbamic acid tert-butyl ester (3.90 g, 9.57 mmol) in MeOH was added 1 M HCl in Et2O (67.0 ml, 67.0 mmol) and the solution was stirred for overnight. The resulting mixture was concentrated to give N2-(4-aminomethyl-benzyl)-N4,N4-dimethyl-quinazoline-2,4-diamine hydrochloride as a white crystalline solid (3.48 g, 95.6%).

Workup

  1. concentrationThe resulting mixture was concentrated

Sources & evidence

ORD record
ord-cd723cce02c84b1db7212ffd65800a52
Source dataset
uspto-grants-2009_06
Patent number
US07544690B2

Reaction notes

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