2,2-Dimethylchroman-6-carboxylic acid → 2,2-Dimethyl-chroman-6-carboxylic acid (3-hydroxymethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-amide

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Reaction Steps

This material was prepared analogous to the procedures described for Example 2, steps (a-b). 2,2-Dimethyl-chroman-6-carboxylic acid (90 mg, 0.4 mmol, Maybridge) and 7-amino-3-hydroxymethyl-3,4-dihydro-1H-quinolin-2-one (85 mg, 0.44 mmol, prepared according to the procedure described in WO03049702) provided the title compound as an off-white amorphous solid. MS (ESI, pos. ion) m/z: 381 (M+1).

Provenance & Evidence