7-Aminoquinoline → 4-bromo-N-quinolin-7-ylbenzamide

HRID 1984975Notes

Reaction equation

HRID 1984975 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH2:11][C:12]1[CH:21]=[C:20]2[C:15]([CH:16]=[CH:17][CH:18]=[N:19]2)=[CH:14][CH:13]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:11][C:12]2[CH:21]=[C:20]3[C:15]([CH:16]=[CH:17][CH:18]=[N:19]3)=[CH:14][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 113777-AminoquinolineHCID 685154-Bromobenzoyl chloride

Product 1

HCID 8314084-bromo-N-quinolin-7-ylbenzamide

Procedure

This material was prepared analogous to the procedure described for Example 1(c). 4-Bromo-benzoyl chloride (2.19 g, 10 mmol, Aldrich) reacted with 7-amino-quinoline (1.22 g, 8.5 mmol, prepared according to the procedure described in WO03099284) to give the title compound. MS (ESI, pos. ion) m/z: 328 (M+1).

Workup

  1. customThis material was prepared analogous to the procedure
  2. customprepared

Sources & evidence

ORD record
ord-2ba21dbe15374c9dbfd51f2d89214263
Source dataset
uspto-grants-2009_06
Patent number
US07544803B2

Reaction notes

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