2-Formylphenylboronic acid → 2'-Formyl-biphenyl-4-carboxylic acid quinolin-7-ylamide

HRID 1984976Notes

Reaction equation

HRID 1984976 reaction equation
Br[C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1.[CH:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O)=[O:22]>>[N:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([NH:8][C:6]([C:5]3[CH:19]=[CH:20][C:2]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=4[CH:21]=[O:22])=[CH:3][CH:4]=3)=[O:7])[CH:18]=2)[CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 2921892-Formylphenylboronic acidHCID 8314084-bromo-N-quinolin-7-ylbenzamide

Product 1

HCID 111872782'-Formyl-biphenyl-4-carboxylic acid quinolin-7-ylamide

Procedure

This material was prepared analogous to the procedure described for Example 1(a). 4-Bromo-N-quinolin-7-yl-benzamide, Example 27, (327 mg, 1 mmol) reacted with 2-formylphenyl boronic acid (183 mg, 1.1 mmol, Aldrich) to give the title compound as a yellow solid. Mp 258-260° C. MS (ESI, pos. ion) nz/z: 353 (M+1).

Workup

  1. customThis material was prepared analogous to the procedure

Sources & evidence

ORD record
ord-c9c6ae45acfb4c5e8525ebfb5147f818
Source dataset
uspto-grants-2009_06
Patent number
US07544803B2

Reaction notes

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