反应详情

A mixture of 1-(1-Benzyl-piperidine-4-yl)-2-ethyl-5-fluoro-1H-indole (2.4 g), 1-(3-Bromo-propylsulfanyl)4-fluoro-benzene (2.4 g), acetonitrile and potassium carbonate is heated under reflux for 5 h. The solvent is removed and the resulting oil is purified with flash column chromatography (1:1 ethyl acetate:petrol ether). The fraction containing the product is freed from solvent and the resulting oil crystallized with ethanol. Yield is 1.2 g (30%) of colourless crystals.

1. temperatureis heated
2. temperatureunder reflux for 5 h
3. customThe solvent is removed
4. customthe resulting oil is purified with flash column chromatography (1:1 ethyl acetate:petrol ether)
5. additionThe fraction containing the product
6. customthe resulting oil crystallized with ethanol