2-(4-{2-[1-(4-Methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester → 2-Methyl-2-{2-methyl-4-[2-(3-methyl-2-oxo-imidazolidin-4-yl)-ethoxy]-phenoxy}-propionic acid ethyl ester

HRID 1985118Notes

Reaction equation

HRID 1985118 reaction equation
[CH2:1]([O:3][C:4](=[O:35])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH:18]2[CH2:22][N:21](CC3C=CC(OC)=CC=3)[C:20](=[O:32])[N:19]2[CH3:33])=[CH:11][C:10]=1[CH3:34])([CH3:7])[CH3:6])[CH3:2]>C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:35])[C:5]([CH3:7])([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH:18]2[CH2:22][NH:21][C:20](=[O:32])[N:19]2[CH3:33])=[CH:11][C:10]=1[CH3:34])[CH3:6])[CH3:2]

Participants

3

Reactant 1

HCID 101956842-(4-{2-[1-(4-Methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester

Product 1

HCID 688672062-Methyl-2-{2-methyl-4-[2-(3-methyl-2-oxo-imidazolidin-4-yl)-ethoxy]-phenoxy}-propionic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2-(4-{2-[1-(4-Methoxy-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (0.105 g, 0.217 mmole) is treated with tryethylsilane (0.064 g, 0.743 mmole) in TFA (8.0 mL) at room temperature for about 6 hours. After evaporating the solvents, the residue is purified using silica gel (0-50% acetone/hexane). Colorless oil (0.041 g, 51%). Mass [EI+] 365 (M+H)+, 729 (2M+H)+.

Workup

  1. customAfter evaporating the solvents
  2. customthe residue is purified

Sources & evidence

ORD record
ord-5876094be9834396943694eaf92c05db
Source dataset
uspto-grants-2009_06
Patent number
US07544812B2

Reaction notes

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