反应详情

The 2-methyl-2-(4-{2-[1-(4-methyl-benzyl)-2-oxo-3-propyl-2,3-dihydro-1H-imidazol-4-yl]-ethoxy}-phenoxy)-propionic acid ethyl ester (0.036 g, 0.075 mmol) was combined with aqueous 5 N NaOH (0.15 mL) in EtOH (5 mL) and heated to reflux under N2 for 1 h. The reaction was cooled and the solvent removed in vacuo to give a residue that was acidified with aqueous 1 N HCl (1 mL). The mixture was extracted with Et2O and water, the organic layer dried (MgSO4), and the solvent removed in vacuo to afford 0.024 g (71%) 2-methyl-2-(4-{2-[1-(4-methyl-benzyl)-2-oxo-3-propyl-2,3-dihydro-1H-imidazol-4-yl]-ethoxy}-phenoxy)-propionic acid. HRMS (ES+) m/z exact mass calcd for C26H33N2O5 [M+0.1] 453.2389, found 453.2387. 1H NMR.

1. temperatureheated
2. temperatureto reflux under N2 for 1 h
3. temperatureThe reaction was cooled
4. customthe solvent removed in vacuo
5. customto give a residue that
6. extractionThe mixture was extracted with Et2O and water
7. dry with materialthe organic layer dried (MgSO4)
8. customthe solvent removed in vacuo